I've been tasked with looking into performance tuning my company's intranet server. It runs DotNetNuke which suffers from poor performance. It also runs a number of other web apps (mix of asp and asp.net).
Could anybody give me a brief list of common performance tweaks that can be made to IIS6?
Why not profile the application and the database as I suggested in the answer I provided to the related question here:
Otherwise you won't know what to tune, you really need to get a full picture of how the app is performing and where the bottlenecks are. You can only get these metrics by profiling, perf counters and tangible data.