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I am looking for a good reference (Paper, Blog, Book etc.) on how a good caching strategy could benefit - especially web based - applications. I know it is always application specific but I just want to quote some figures about the performance gains possible (or when it doesn't make sense). Would be great if you had some input for me.

A: 

There's a decent paper (published in the ACM) called "Quick and Easy Cache Performance Analysis". You might find it useful.

If you can't download that paper, let me know and I'll send it to you.

An Onion That is Red