I'm not sure if this is exactly possible, but figured I'd throw it out there.
I have a client that is getting some hate-mail from somebody he knows via a contact form on a website that I developed for him. Currently I do the normal checks for a validly-formatted email address, along with a Captcha, but the client has requested that a user enter his/her own email address in the form.
Now I realize that something like this could be easily spoofed by setting up a fake Yahoo account, etc, but the client's thinking is that this person is not quite that computer-literate.
Is there any possibility for checking if an email address is valid and in-use? The only other things I can think of is turning his contact form into a mailto: link.