Since you don't say if it's desktop or browser based, I'll take a stab at desktop.
I liked Lie Ryan's suggest to make it a command line program with a really good api, so that others can build a gui. A very unix-like approach, which also allows the input of other programs to pipe into yours and the output of your program to pipe into others.
If you want something extremely professional, Microsoft have spent hundred of millions watching how people use programs and refining their interface. Recommended reading is here http://msdn.microsoft.com/en-us/library/ms993296.aspx I guess that would go for platforms other than windows.
Now, that refers to design/layout of controls and, to some extent generic program operation. I am not sure if you want that, or just a program to help you build GUIs.
Whatever you do I would *strongly*advise you to keep your program like pothers - like people have gotten used to. E.G a "file" menu on the left, even if you don't do anything with files. It probably ought to have been called "application", but it's too late now, people expect "file". "Help menu on the right". Dialog boxes with Ok on the left (as default) and cancel on the right. Hot-keys for the rodent-phobic, etc, etc.
Now, if what you want is just a RAD GIU builder, then check out the free edition of Borland Delphi 7 if you like Pascal or are afraid of C+ (I personally prefer Borland products because of the thousands of free components available; I am unaware of any competitor with so many, but would be happy to be corrected).
If you are comfortable with C++, check out MS's free C++ RAD GUI at http://www.microsoft.com/express/Downloads/ or QtBuilder, which is free and cross-platform.
Of course, if you want cross-platform you can also use Java. In any case, look at NetBeans, which supports many languages.
And if you use Linux exclusively, I would recommend KDevelop, even if you use the GNOME desktop.
I may have answered the wrong question here, as the original was not very clear, but I hope that this has been of some use to someone.