I've found that "normal" sequence diagrams are almost always more of a pain than they're worth (although I have found them useful for showing data flow in LINQ). Doing a "rough and ready" diagram and explaining it (preferably in person, but with plenty of words either way) works better in my experience.
I think it's a good idea to have a diagram (or several) showing a sort of "vertical slice" of your application - how each layer talks to another, and perhaps showing the course of a request/response in suitable cases. However, this doesn't need to be at the "individual method call and always 100% accurate" level - making sure that you convey the right general impression is more important, assuming the reader can then dive into the real code.
Having said all of this, my views on UML in general are much the same, so if you're a big fan of precise diagrams always being kept meticulously in sync with reality etc, take it all with a pinch of salt :)