Having played around a little with both Tkinter and wxPython, I like Tkinter much better in terms of how clean my source code looks. However, it doesn't seem to have as many features; in particular it doesn't have tabs (as in, the tabs at the top of a Firefox window).
A little Googling on the subject offers a few suggestions. There's a cookbook entry with a class allowing you to use tabs, but it's very primitive. There's also Python megawidgets on SourceForge, although this seems very old and gave me errors during installation.
Does anyone have experience making tabbed GUIs in Tkinter? What did you use? Or is it simply the case that anyone who needs more powerful windowing components has to use wxPython?