What is the best API to utilize in developing an application that handles both realtime MIDI and audio input and output? This would be for an application that is used in the process of making music as opposed to playing audio or MIDI files. I'm aware that this may be a subjective question, but if you know of an API that is dominantly used for these purposes, please share it.
I'm agnostic about which language the API is for, and I also don't care about portability. The real concern is for an API that is well documented, well designed (e.g. thought out and intuitive to developers using it), and actively maintained. OS portability would be nice, but it is second to having an API/Language that meets the previous requirements.
Please note that the emphasis is not on API's for sound synthesis or for composing music with code. It is intended for the handling of sound file and MIDI data in a real-time context.