No.
In theory there could be a plug-in that provides custom protocol used via <video>
:
<video src="drm:…">
In practice there is none, and it would be dumb to replace Flash with another plugin that has same downsides and none of the benefits.
Consider abandoning idea of DRM, as it's more likely to backfire than protect the content.
If you really, really have to do something, you could generate video element and URL with hard-to-debug JS, serve file with specifically-crafted server that refuses to send same URL twice (will kill seeking though), and overlay <div>
or transparent image on top of video to make "Save As" harder to reach,.
This is of course pointless cat-and-mouse game, and you'll be in losing position, alienating your users.