In his blog post, Scott Guthrie describes how to enable validation using DataAnnotations.
Example:
public class Product
{
    [Display(Name="Product Number")]
    [Range(0, 5000)]
    public int ProductID { get; set; }
    [Display(Name="Name")]
    [Required]
    public string ProductName { get; set; }
    [Display(Name="Price")]
    [DataType(DataType.Currency)]
    public double ListPrice { get; set; }
}
In the comments to this blog post @Ke wrote:
How do the server side validations work with ajax post? i.e, how can i send the validation errors back to the client?
Scott replied with:
Yes - you can handle this. I believe Phil Haack has it on his list to blog about soon.
I cannot find this blog post though. How do I combine server-side validation with an AJAX post?
The best options I've seen seem to involve using partials to send the form back to the client. I would rather use client-side Javascript to enable the error messages.