No. Completely agree with the answer from fuzzy lollipop. If you’re talking to a remote machine, the data can always be faked. Always always. What makes you certain you’re even talking to a mobile device at all? The User-Agent string? Pfft, it can be faked. Talking to a GPS? Pfft, could be coming from a predefined path. Talking to a web browser? Pfft, could be a bot, or some other malware.
And don’t think encryption (i.e. HTTPS) is going to help you. The client could edit any of your HTML, CSS, or JavaScript on-the-fly — take Firebug or Greasemonkey for example.
The reasons why you can’t trust the client are the same as the reasons why exploits such as SQL or HTML injection are so common. Ever heard the phrase “the customer is always right”? Well, the customer may be right, but the client is always untrustworthy.
The system is there to be gamed. As flaws are discovered, you patch them one by one. It’s more like leapfrog, rather than achieving the holy grail. Bruce Schneier’s quip “security is a process, not a product” comes to mind. Asking for a system that “can’t be gamed” is missing the point. What you need to be doing is creating a system where the server sanitises the data, and/or rejects bad data — fuzz testing is not a bad idea, either.
That’s about the best you can do without shipping custom untamperable mobiles to your customers with the OS in ROM, and the inside sealed with epoxy.