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for those of us who are developers, the main concern above all is speed, speed and speed. i have spend years developing a websites from those little ones to big stores, web applications and so on.

but my main goal besides a lot of other things :) was speed, so what technologies currently available and what best practices should be used in order to build a really fast web application whitch operates with tremendous amount of information?

my best experiencies on server side are with php in combination with mysql and sphinx ... what about new hphp? on the client side there have been write quite a lot tips and tricks to achieve fast web page loading starting with compressed javascrit files ending with short css class names

what are yours techniques / ideas / experiencies? im sure that there is still much to be learn. for example what are those people doing in facebook, where is the secret?