The built-in IntelliSense in VS2010 is a million times better than what was in VS2008. It's perhaps not quite as good as what's available with Visual Assist X, but IMO if you're not using VAX, then it's worth the upgrade just for that.
The build system is now based on msbuild as well, which doesn't actually make it all that much faster (I never ran any tests, but it "feels" about the same to me).
As for the interface, I've never had any problems with it. It seems about as fast (if not, faster in some cases) than the VS2008 interface. That doesn't say a lot about how good it is, of course, just how bad VS2008 was in comparison :-)