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My friend asked me to make a registration software for his blood donation camp. He told me that he can't host an ASP.NET or PHP page.

Also that since they'll be running the software in many systems, which may not be interconnected, they may not be able to use a Database server.

Is there a way to store/read data from an MS-Excel or MS-Access file instead of any other database?

Also that I wish to make the front end using HTML & JavaScript/JQuery.

+1  A: 

As you problem is little bit twicky. Since your app will run on various machine so you want to develop standalone app in Html / Jquery. Also you cannot use db server bcoz of lack of connectivity. So in such scenario i will suggest you to go for Win Form app with a lightweight db like MS Access and Sqlite. Which ever you prefer. Since you are keeping Network aside so i suggest you to not use HTML/Jquery to use access or Excel as it looks logical very easy to use interop with excel but implementation is quite messy. In that time you can finalize the winform app with any of the database with lots of ease.

Amit Ranjan