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answers:

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Is it possible to disable "edit item" in a Sharepoint List when a custom workflow is running? Maybe a property in the workflow that can be affected?

Thanks, David Esteves

A: 

You can use a custom activity to set read-only permissions on the item in the beginning of the WF and then to restore the original permissions in the end. Take a look at this selection of custom activities at CodePlex: link text

Vladi Gubler