Can you
Mapper.CreateMap<Foo, Bar>()
.ForMember(x => x.IsFoo, x => x.Ignore());
and then later on add another mapping of the sort
.ForMember(x => x.IsBar, x => x.Ignore());
or even change the old one
.ForMember(x => x.IsFor, x => x.MapFrom(z => z.IsBar));
? If so, how?