I am thinking about something that would allow to develop applications independent of the GUI library, but allow Qt and GTK being plugged in as needed.
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5Qt is a framework, it uses GTK underneath (at least on Unix).
There was a mobile toolkit that let you write everything in JS but compiled to the native code on each platform. I forget the name but it was a victim of the iPhone lockdown.
You can try to use wxWidgets but you tend to get "lowest common denominator" if you go that route. Your better bet is to design your software such that you can plug in an implementation of the necessary "views" in the desired toolkit, and keep your core UI toolkit independant.
Obviously this is more work, but if there is a strong business need, then so be it.
I don't know of any framework doing something like that (I don't know how it could possibly be done without suffering from a heavy "lowest-common-denominator" syndrome), but I do "cross toolkit" development (applications that use more than one GUI toolkit) and I wrote an article about why and how to do it:
http://www.hardcoded.net/articles/cross-toolkit-software.htm
You can try Tk, which supports themes. There is a tile-qt and tile-gtk theme. There is a 2010 Google Summer of Code project to improve these themes. And, of course, when you use Tk you also get support for Windows and OSX out of the box.
I'd just use Qt. It includes a Gtk-like style, mimics Gtk standard dialogs and even uses Gtk file dialogs if run under Gnome, so basically it integrates itself into Gtk as good as anything (except Gtk of course), or at least it integrates itself better into Gtk than Gtk does into Qt.