We're using DevTrack company-wide - a choice made some 2 years ago and before I joined the company. Having past experience with Mantis, Track and Jira, I'm deeply in pain using this tool. It takes a lot of work to perform basic tasks, like adding comments or submitting new issues. There's also no way for me to "watch" a ticket, that is receive notification of changes made to it, unless I owned it at some point. It uses JavaScript to trigger functions and you can't copy the URL of any ticket page. We need to exchange ticket numbers and look them up each time.
It is powerful and highly configurable, but I wish they worked more on usability.
If you do have a choice, stay away from DevTrack and go for FogBugz or Jira instead.