I've played around with GTK, TK, wxPython, Cocoa, curses and others. They are are fairly horrible to use.. GTK/TK/wx/curses all seem to basically be direct-ports of the appropriate C libraries, and Cocoa basically mandates using both PyObjC and Interface Builder, both of which I dislike..
The Shoes GUI library for Ruby is great.. It's very sensibly designed, and very "rubyish", and borrows some nice-to-use things from web development (like using hex colours codes, or :color => rgb(128,0,0)
)
As the title says: are there any nice, "Pythonic" GUI toolkits?