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Choosing a web application framework in python

If you were to create a new web app in Python from scratch now, which web framework would you choose and why? If Django is your favorite for example, why do you prefer it over others? For what kind of web apps is it suitable or unsuitable? What are the advantages and disadvantages?

Thank you so much for your answer in advance.

+3  A: 

Django. I think the killer feature of Django is the automatic admin interface.

Here is a list of frameworks to choose from though:

http://wiki.python.org/moin/WebFrameworks

Justin
+1  A: 

+1 for django. I was very skeptical to even try a large framework because it seemed like overkill to me. However, at work we create a lot of data entry applications and have completely switched everything from a custom framework to Django. Django's ModelForms that tie the forms to the ORM is absolutely beautiful.

Aaron