I'd consider refactoring your model domain. Obviously the hash represents something tangible. Why not make it an object? If the item can be completely represented by a hash, you may wish to subclass Hash. If it's more complicated, the hash can be an attribute.
Secondly, the reason for which you are checking blanks can be named to better reflect your domain. You haven't told us the "why", but let's assume that your Item is only valid if it doesn't have any blank values.
class MyItem < Hash
def valid?
!invalid?
end
def invalid?
values.any?{|i| i.empty?}
end
end
The point is, if you can establish a vocabulary that makes sense in your domain, your code will be cleaner and more understandable. Using a Hash is just a means to an end and you'd be better off using more descriptive, domain-specific terms.
Using the example above, you'd be able to do:
my_item = MyItem["a" => "1", "b" => "", "c" => "2"]
my_item.valid? #=> false