Asking and answering my own question here, because I had a dickens of a time finding this online:
Caused by: java.lang.NullPointerException
at com.sun.xml.ws.model.JavaMethodImpl.freeze(JavaMethodImpl.java:367)
Trying to call a web service from inside Glassfish v3. Works fine from JDK1.6.0_21
This is caused by a mismatch between the java interfaces and the WSDL you are attempting to bind to. It is supposedly "fixed" in the next version, but right now it fails with a cryptic message. The difference between the JDK JWS client and the Glassfish is how strict they are. If you have a remote @WebMethod that returns void and doesn't throw a checked exception, you have to use the @Oneway annotation on that method in the interface.