If so, please explain how.
Re: what is distance -- "The distance between two strings is defined as the minimal number of edits required to convert one into the other."
For example, xyz to XYZ would take 3 edits, so the string xYZ is closer to XYZ and xyz.
If the pattern is [0-9]{3} or for instance 123, then a23 would be closer to the pattern than ab3.
How can you find the shortest distance between a regexp and a non-matching string?
The above is the Damerau–Levenshtein distance algorithm.
If you mean the string with the smallest levenshtein distance between the closest matched string and a sample, then I'm pretty sure it can be done, but you'd have to convert the Regex to a DFA yourself, then try to match and whenever something fails, non-deterministically continue as if it had passed and keep track of the number differences. you could use A* search or something similar for this, it would be quite inefficient though (O(2^n) worst case)
You can use Finite State Machines to do this efficiently (that is, linear in time). If you use a transducer, you can even write the specification of the transformation fairly compactly and do far more nuanced transformations than simply inserts or deletes - see wikipedia for Finite State Transducer as a starting point, and software such as the FSA toolkit or FSA6 (which has a not entirely stable web-demo) too. There are lots of libraries for FSA manipulation; I don't want to suggest the previous two are your only or best options, just two I've heard of.
If, however, you merely want the efficient, approximate searching, a less flexibly but already-implemented-for-you option exists: TRE, which has an approximate matching function that returns the cost of the match - i.e., the distance to the match, from your perspective.