There are a number of GUI Toolkits available for Python. Obviously, the toolkit you choose will determine your selection of 3rd party widgets.
The Contenders
Python comes with Tkinter which is easy to use, but not great looking.
There are some very popular cross platform GUI toolkits borrowed from C/C++ that have a lot of external widgets: wxPython, pyQt, pyFLTK, pyGtk
I also know of, but have not used some of the other toolkits that are out there: PyGUI, Easygui, PythonCard
My Choice
I'm a fan of wxPython. They have a nice selection of widgets, some great examples that come with the install, good documentation, a book, and an active community.
WxWidgets has additional components offered by the community called wxCode.
Quote about wxPython from the creator of Python:
wxPython is the best and most mature cross-platform GUI toolkit,
given a number of constraints. The only reason wxPython isn't the
standard Python GUI toolkit is that Tkinter was there first.
-- Guido van Rossum