If you have a single server I think that the main key is, apart from everything already mentioned, is don't skimp on the specs of it. Trying to get too much to run on too little is just a recipe for disaster.
It is also a good idea to get monit or God monitoring your thin instances, I started out with God, but it leaked memory pretty bad on Ruby 1.8.6 so I stop using it in favour of monit. Monit is written in C I believe and has a tiny memory footprint so I'd recommend that one.
If all that seems like a bit much to keep nginx and thin playing nicely you may want to look into an all in one solution like Passenger or LiteSpeed. I have very little experience with these so can offer no substancial advice for them.