I've always used the analogy between monitor size (resolution) and desktop size - larger screen, more space to spread out and work.
More important than the physical size is how you set it up - most people have their monitors set way way too bright.
I typically start with maximum contrast and minimum brightness, and work from there. The black on your screen should be real black, not dark gray; the white on your screen should be no brighter than a piece of paper held up next to it.
That said, I do have good screens. At work, dual 22" 1680x1050 LCD; at home, dual 19" 1200x1024 CRT; and my laptop is 1920x1200 17". I've trialled a single 24" LCD - was really nice, not as wide as either dual monitor setup.
Updated 1 Mar: The suggestion from rtpearson
to look away from the monitor regularly is good advice.
I was told (years ago) that it is important for your eyes to change focal length regularly.
If you have a seat next to a window, glancing outside while you think is a good way to achieve this. "Walking an email" to a colleague on the same floor can help as well. Using a timer (such as this one I wrote) to remind you to take breaks and rest your eyes is also useful.