Assume all traces of Office 2003 will be removed from the computer.
UPDATE:
I understand that I will still be able to use .xls files. I'm asking about automating Excel through the COM interop from outside Excel. When I add a reference to Excel to a VB project, it gives me a different version of the dll for different versions of Excel. If a program was compiled with a reference to Office 2003's dll, will it need to be recompiled for Office 2007? Will the code need to be updated to use the new dll?