That is definitely possible. The configuration would look something like this (not checked for syntactic correctness):
<log4j:configuration xmlns:log4j="http://jakarta.apache.org/log4j/">
<appender name="console" class="org.apache.log4j.ConsoleAppender">
...
</appender>
<appender name="otherAppender"
class="org.apache.log4j.FileAppender FileAppender">
...
</appender>
<logger name="com.mycompany.mypackage.MyClass">
<level value="info"/>
<appender-ref ref="otherAppender" />
</logger>
<root>
<priority value="debug" />
<appender-ref ref="console" />
</root>
</log4j:configuration>
All debug and info messages go to the console
appender. Info messages go to otherAppender
.