I found http://www.iseriespython.com/, which is a version of Python for the iSeries apparently including some system specific data access classes. I am keen to try this out, but will have to get approval at work to do so. My questions are:
Does the port work well, or are there limits to what the interpreter can handle compared with standard Python implementations?
Does the iSeries database access layer work well, creating usable objects from table definitions?
It sounds like it is would work as expected. Support for other libraries might be pretty limited, though.
Timothy Prickett talks about some Python ports for the iSeries in this article:
http://www.itjungle.com/tfh/tfh041706-story02.html
Also, some discussion popped up in the Python mailing archives:
http://mail.python.org/pipermail/python-list/2004-January/245276.html
Another place to look is on the mailing list MIDRANGE-L or search the archives for the list at midrange.com. I know they have talked about this a while back.
From what I have seen so far, it works pretty well. Note that I'm using iSeries Python 2.3.3. The fact that strings are natively EBCDIC can be a problem; it's definitely one of the reasons many third-party packages won't work as-is, even if they are pure Python. (In some cases they can be tweaked and massaged into working with judicious use of encoding and decoding.) Supposedly 2.5 uses ASCII natively, which would in principle improve compatibility, but I have no way to test this because I'm on a too-old version of OS/400.
Partly because of EBCDIC and partly because OS/400 and the QSYS file system are neither Unix-like nor Windows-like, there are some pieces of the standard library that are not implemented or are imperfectly implemented. How badly this would affect you depends on what you're trying to do.
On the plus side, the iSeries-specific features work quite well. It's very easy to work with physical files as well as stream files. Calling CL or RPG programs from Python is fairly painless. On balance, I find iSeries Python to be highly usable and very worthwhile.
I got permission to install iSeries Python on a box about 3 years ago. I found that it worked pretty much as advertised. I contacted the developer and he was very good about answering questions. However, before I could think about using it in production, I had to approach the developer regarding a support contract. That really isn't his gig, so he said no and we scrapped the idea. The main limitation I found is that it is several releases behind Python on other platforms.
I have also had very good experience with Jython on the iSeries. Java is completely supported on the iSeries. Theoretically, everything you can do in RPG on the iSeries, you can do in Java, which means you can do it in Jython. I was sending email from an AS/400 (old name for iSeries) via JPython (old name for Jython) and smtplib.py in 1999 or 2000.
iSeriesPython is working very well. We are usning it since 2005 (or earlier) in our Development and Production Environments as an utility language, for generating of COBOL source code, generating of PCML interfaces, sending SMS, validating/correcting some data ... etc. With iSeriesPython you can access the iSeries database at 2 ways: using File400 and/or db2 module. You can execute OS/400 commands and you can work with both QSYS.LIB members and IFS stream files. IMHO, iSeries Python is very powerful tool, more better than REXX included with iSeries. Try it!