To start with, look for the topmost line that looks something like "ntdll.dll+0x2000".
If the hotspot is occurring in your native code (i.e. the DLL is one of yours), then find out how to persuade your compiler to produce a list of mappings from DLL offset to line number. Obviously, that may mean you need to re-run with the newly compiled DLL and wait for the problem to occur again.
Otherwise, see if searching for that specific line brings up something in Google, bearing in mind that the same error could mean a whole host of things. And see if the DLL name looks like it's something recognisable, e.g. a printer driver name, graphics driver, or some other component that you can track down to a particular call. Whatever that component is, you may be able to upgrade it to a fixed version, or avoid making the call in question. If you're not sure what the component is, it may just be "the JVM" that you need to upgrade-- upgrading at least to the latest update/minor version nubmer of whatever version you're on is probably a good idea.
In the past I've also seen bugs in the JIT compiler that can be temporarily solved by telling it not to attempt to compile the particular method in question-- as I recall vaguely, in these cases, the hotspot error gives some clue as to which method it was (possibly just the dump of the Java stack), but I don't have an example to hand to recall the details.