Yes it's possible, i've done it in the past without using jQuery.
I have a the following markup:
<div id="HorThumbs" style="overflow:hidden;width:500px">
<div id="HorScroller" style="width:1000px">
//Data to be shown
</div>
</div>
var scrollStep=1;
var timerLeft,timerRight="";
function scrollDivLeft(id){
clearTimeout(timerRight);
document.getElementById(id).scrollLeft-=scrollStep;
timerRight=setTimeout("scrollDivLeft('"+id+"')",1);
}
function scrollRight(id){
clearTimeout(timerLeft);
document.getElementById(id).scrollLeft+=scrollStep;
timerLeft=setTimeout("scrollRight('"+id+"')",1);
}
Then add a MouseOver event to your left and right arrows, passing in 'HorThumbs' as the Id to either scrollDivLeft or scrollDivRight function.