I tend to have light sources on the left and right of my monitor, since most people look more left-to-right than up-and-down. And basically, this light source is just a window during daytime. It also means that the sun is shining against the back of your monitor, thus lessening the sun glare in your screen.
At night, I just use the lamp on the ceiling but it's adjusted to shine on my desk to my left and right. At home, I also have a keyboard with build-in lights for every key, which makes it easier to type in the (accidental or game-play) dark.
Also, to reduce eye-strain, I'm avoiding large blocks of white on my screen by just changing the display properties and changing the white color for windows backgrounds to a pale yellow or green.