Numerical Analysis teaches us that you can't rely on the precise value of small differences between large numbers.
This doesn't just affect the equation in question here, but can bring instability to everything from solving a near-singular set of simultaneous equations, through finding the zeros of polynomials, to evaluating log(~1) or exp(~0) (I have even seen special functions for evaluating log(x+1) and (exp(x)-1) to get round this).
I would encourage you not to think in terms of zeroing the difference -- you can't -- but rather in doing the associated calculations in such a way as to ensure the minimum error.
I'm sorry, it's 43 years since I had this drummed into me at uni, and even if I could remember the references, I'm sure there's better stuff around now. I suggest this as a starting point.
If that sounds a bit patronising, I apologise. My "Numerical Analysis 101" was part of my Chemistry course, as there wasn't much CS in those days. I don't really have a feel for the place/importance numerical analysis has in a modern CS course.