One problem with using them (for me anyway) is that in MSVC you have to include iso646.h
or use the (mostly unusable) /Za switch.
The main problem I have with them is the Catch-22 that they're not commonly used, so they require my brain to actively process the meaning, where the old-fashioned operators are more or less ingrained (kind of like the difference between reading a learned language vs. your native language).
Though I'm sure I'd overcome that issue if their use became more universal. If that happened, then I'd have the problem that some boolean operators have keywords while others don't, so if alternate keywords were used, you might see expressions like:
if ((x not_eq y) and (y == z) or (z <= something)) {...}
when it seems to me they should have alternate tokens for all the (at least comparison) operators:
if ((x not_eq y) and (y eq z) or (z lt_eq something)) {...}
This is because the reason the alternate keywords (and digraphs and trigraphs) were provided was not to make the expressions more readable - it was because historically there have been (and maybe still are) keyboards and/or codepages in some localities that do not have certain punctuation characters. For example, the invariant part of the ISO 646 codepage (surprise) is missing the '|
', '^
' and '~
' characters among others.