+1 for Qt
I have used both wxWidgets and Qt extensively on different projects for the Windows platform writing C++ applications.
Having used both and compared the two after, I would absolutely use Qt over wxWidgets. You need to consider (as some of the others have pointed out) if the re-factoring effort is is something you have time for and are willing to do.
Also consider the cost -- this may not matter in your situation, but unlike wxWidgets, the Qt Library is not free for commercial use. I have spoken to TrollTech at length and read through their licensing agreement to verify this; you definitely have to pay unless you GPL your application.
Regarding licensing see:
http://qt.nokia.com/about/licensing/frequently-asked-questions
"Will you continue to offer Qt under a
commercial license?"
"Yes, absolutely. Our commercial
licensing will continue."
"Why would I want to buy a commercial
license? What is the difference?"
"The commercial Qt license includes
email support, access to upgrades and
allows you to develop fully closed
source software. The LGPL carries some
restrictions regarding the ability for
users to relink libraries and other
restrictions that may impose
architectural requirements that some
organizations might not be comfortable
with."
Qt is definitely worth the money though, even if you are not doing cross-platform development. It has a lot more and better documentation. Qt and wxWidgets are not perfect... The fact that they are bloated and provide APIs for networking, data structures, and database handling is not necessarily a good thing. Sometimes sticking with the STL or Boost libraries (if you're coding in C++) is a much better solution.
Good luck.
-bn