Imagine you are on Windows 7 and you have to write a GUI for a GRAPHIC application, (like a terrain editor, mesh viewer ..) which involves a great use of DirectX and OpenGL (so written in native C++). If your goal is a multi-platform software then you should go for wxWidgets, but imagine you're doing a Windows' only app...what would your choice be? and why?
I'm supposing that the application would work on both XP and Vista/7 and obviously in the WPF case the UI will be managed, but it will call native functions by a C++/CLI proxy-like class ( will "bouncing" from managed-native and native-managed cause performance issues? ).