"Encrypting" Python source code (or bytecode, or really bytecode for any language that uses it -- not just Python) is like those little JavaScript things some people put on web pages to try to disable the right-hand mouse button, declaring "now you can't steal my images!"
The workarounds are trivial, and will not stop a determined person.
If you're really serious about selling a piece of Python software, you need to act serious. Pay an attorney to draw up license/contract terms, have people agree to them at the time of purchase, and then just let them have the actual software. This means you'll have to haul people into court if they violate the license/contract terms, but you'd have to do that no matter what (e.g., if somebody breaks your "encryption" and starts distributing your software), and having the actual proper form of legal words already set down on paper, with their signature, will be far better for your business in the long term.
If you're really that paranoid about people "stealing" your software, though, just stick with a hosted model and don't give them access to the server. Plenty of successful businesses are based around that model.