I don't use a mac, but here's the info i know, combined with the information i gathered on the web. The first thing to know is that most boost libraries do not require any compiled binaries. But i am guessing you know that and want to use other libraries, such as datetime or regex.
To compile boost libraries, the official way is to use a tool named bjam. Download it there (Latest link may be found there).
The command line to use to compile boost libraries using bjam is shown in the following link.
bjam --toolset=darwin --build-type=complete --with-thread
--with-date_time --with-filesystem
--with-regex --with-system architecture=combined
UNTESTED (by me), but all the sources i found suggest this is the right approach.