App.Config CAN be changed...however it exists in a location akin to HKEY___LOCAL_MACHINE i.e. the average user has read-only access.
So you will need to change it as an administrator - best time would be during installation, where you're (supposed to be) installing with enhanced permissions.
So create an Installer class, use a Custom Action in the setup project to pass in the user's choices (e.g. "/svr=[SERVER] /db=[DB] /uilevel=[UILEVEL]") and, in the AfterInstall event, change the App.Config file using something like:
Public Shared Property AppConfigSetting(ByVal SettingName As String) As Object
Get
Return My.Settings.PropertyValues(SettingName)
End Get
Set(ByVal value As Object)
Dim AppConfigFilename As String = String.Concat(System.Reflection.Assembly.GetExecutingAssembly.Location, ".config")
If (My.Computer.FileSystem.FileExists(AppConfigFilename)) Then
Dim AppSettingXPath As String = String.Concat("/configuration/applicationSettings/", My.Application.Info.AssemblyName, ".My.MySettings/setting[@name='", SettingName, "']/value")
Dim AppConfigXML As New System.Xml.XmlDataDocument
With AppConfigXML
.Load(AppConfigFilename)
Dim DataNode As System.Xml.XmlNode = .SelectSingleNode(AppSettingXPath)
If (DataNode Is Nothing) Then
Throw New Xml.XmlException(String.Format("Application setting not found ({0})!", AppSettingXPath))
Else
DataNode.InnerText = value.ToString
End If
.Save(AppConfigFilename)
End With
Else
Throw New IO.FileNotFoundException("App.Config file not found!", AppConfigFilename)
End If
End Set
End Property