Create a workbook that contains the worksheet. Save workbook as a template if needed. Embed workbook as a resource. How you convert resource into workbook/worksheet will depend on the document format. If SpreadSheet XML (XMLSS), it is fairly easy. If binary (xls or xlt) then you will have to manipulate resource. Excel cannot read a stream.
Sample Using VSTO Excel Add-In Project and Project Resource
Public Class ThisAddIn
Private Sub ThisAddIn_Startup(ByVal sender As Object, ByVal e As System.EventArgs) Handles Me.Startup
' Start of VSTO generated code
Me.Application = CType(Microsoft.Office.Tools.Excel.ExcelLocale1033Proxy.Wrap(GetType(Excel.Application), Me.Application), Excel.Application)
' End of VSTO generated code
'setup a workbook and worksheet for sample code to work
Dim oWB As Excel.Workbook = Me.Application.Workbooks.Add()
Dim oWS As Excel.Worksheet = CType(oWB.Worksheets.Add, Excel.Worksheet)
'create temporary template
Dim sPath As String = My.Computer.FileSystem.GetTempFileName
My.Computer.FileSystem.WriteAllBytes(sPath, My.Resources.Book1, False)
'open with excel
Dim oTemplate As Excel.Workbook = Me.Application.Workbooks.Add(sPath)
'specify worksheet from a different workbook
' copies the template worksheet into destination workbook
oTemplate.Worksheets.Copy(oWS)
'no longer need template
oTemplate.Close()
'delete the temporary file
My.Computer.FileSystem.DeleteFile(sPath)
'get our worksheet
Dim oReportWS As Excel.Worksheet = CType(oWB.Worksheets.Item("Template"), Excel.Worksheet)
'write our data
CType(oReportWS.Cells(1, 1), Excel.Range).Value2 = "Here I am!"
End Sub
End Class