For tools such as unity, corona, flash, and other platforms used to 'generate' iphone apps, Apple may be able to 'decompile' and examine your app (look at patterns of generated functions, etc). From this, they might be able to guess that your app was generated with such a tool.
In the limit, this is impossible. Consider the following: I write some script code to generate a bunch of objective-c code. Then I manually import the objective-c files into xcode and build the app. How would apple be able to distinguish the script-generated code from human-written code? Maybe I just tend to write code that happens to look machine-generated. There's no way for apple to determine whether the code was "originally written in objective-c, c, c++ or javascript" or not, yet this would still, technically, violate the agreement. That's why the 3.3.1 part of the agreement is nonsense.