I always run into the same problem when creating web pages. When I add a font that is larger then about 16-18px it looks terrible. Its jagged, and pixelated. I have tried using different fonts and weights, however I haven't had much luck there.
Note: Its only in windows that it is like this. Mainly in Opera and FF also in IE7 but not quite as bad. In Linux the font looks good. I haven't looked at a Mac.
What do you guys do to fix this? if anything. I noticed that the titles here on SO are also pretty jagged but they are just small enough not to look bad.