Most Internet companies are based in the US. Some start to appear in (eastern) Europe, Australia and Israel. What are the advantages and challenges of such 'foreign' companies, baring in mind that most of the Internet's activity, hype and bandwidth are still US centric?
edit: Mind you, Israel has its own Paul Graham like startups hub. The obvious place would be Tel Aviv through neighboring suburbs seem to be gaining traction. I was thinking more along the lines of being removed from the heart of the Internet culture, which is basically american.