I would say that the worst problem in game design is the need to "stretch" the game to meet some metric of "not being too short" and thus a waste of money. In order to accomplish that, designers ramp up the difficulty, add side missions, remove save points, etc.
Unfortunately, no matter how much you "stretch" a game, an X amount of content and novelty would only get you this far.
What ends up happening is that there are so many games coming out, that enough people will abandon your game once it becomes repetitive.
This has happened to games like Assassin's Creed that was supposed to be a great new thing, and everyone complained that was too repetitive. I admit that I eventually skipped most of the side quests in Mass Effect when they added very little. I was getting very annoyed with Bioshock towards the end. I also left GTA4 very early though at least there each side mission has a lot of humor and banter. I am probably close to my breaking point with FAllout 3.
I'd rather enjoy every minute of a 10-hour game (Halo 3), than spend 50-hours doing the same thing over and over again with different textures, especially as enemies become stronger while my weaponry becomes stronger.
In addition, if you're looking for specific annoying thingS:
- Game without subtitles are bad. Games without option of skipping (and repeating) speech sequences are bad. Games where you can't skip the speech and every answer is like listening to John Kerry are also bad.
Too much stuff to pick and no convenient ways of "auto picking" everything on the screen. This happens with games like Fallout a lot. I spend half the time feeling like someone picking up trash on the side of the highway looking for what is a good skill book among tons of ruined boosk, for example.
An AI that is still to freaking dumb or that can be easily brought into dumb states.
"Nonlinear" games with a lot of side missions where there was an expectation of a certain order to said missions. Fallout 3 is case in point. Since it is fairly random when you encounter side-quests and locations, you can very easily end up in places that are above your skill level (frustrating), or way below your skill level (frustrating).