I haven't found a definitive list out there, but hopefully someone's got one going or we can come up with one ourselves. What causes disruptions for .NET applications, or general service disruption, running on IIS? For instance, web.config changes will cause a recompilation in JIT (while just deploying a single page doesn't affect the whole app), and iisresets halt everything (natch, but you see where I'm going). How about things like creating a new virtual directory under a current web app?
It's helpful to know all the cases so you know if you can affect a change to a server without causing issues with the whole thing.
EDIT: I had IIS 6 in mind when I asked, but of course a list of anything different in other versions would be helpful as well to people.