I have a aspx page that contain "asp:RequiredFieldValidator" controls;Problem that is when each of "asp:RequiredFieldValidator" controls activate and show their messages; other controls in my page don't working even "CANCEL" button!!! i want to enable controls in my "NEXT" button MouseDown and then disable them at my "NEXT" button MouseUp. Thanks for any other solutions...
Specifically to answer your question as stated in your title: to add additional event handlers to an asp:button or other server controls that are not composite you simply add the handler to the element. Include onmousedown="myMouseDownHandler(this);" in the element and the javascript function myMouseDownHandler will fire.
However, I think there is a better way to do what your asking but the description of the question is not coherent enough for me to quite figure out what you're asking. I realize you may not be a native English speaker but perhaps you could give it another pass.
Use ValidationGroup property on controls that are validated and controls that triggers validation (e.g. save/update buttons) and on validators.
Additionally set CausesValidation property to false on each button that does not need to trigger validation (cancel button).