True security.
I want to be able to run any program I download off the Internet and not have to worry about it being a virus. I want an operating system that has defined security so well that there doesn't need to be anti-virus or firewalls anymore.
Sandboxing is the key, but also fine level security. For example by default, a program should only receive keyboard or mouse input when it is in focus. A program, should never be able to change its own window state. A program cannot write or read from disk until told so by the user. A program cannot take a screen shot of your desktop. A program has no network access. A program has no hardware access. A program has limited memory and CPU usage.
Secure computing by default
Whenever you run or install anything, it should never "hook" into the OS. It should never replace a core function of the OS, this includes drivers.
The user should be able to control the OS at all times, and the OS in turn should be able to control all programs at all times. This way when a program fails, it doesn't crash the entire computer. The OS should never say "well, the program used our API improperly, therefore all we could do is crash".