Here's a specific example based on the answers given by danielpunkass and Peter Hosey:
NSDictionary *attributes = [NSDictionary dictionaryWithObjectsAndKeys:[NSFont fontWithName:@"Helvetica" size:12]];
NSAttributedString * text = [[NSAttributedString alloc] initWithString:@"Hello" attributes: attributes];
NSSize textSize = [text size];
For those new to Objective-C/Cocoa like myself an example really goes a long way. If you're coming from C++/Java/C# or whatever the Objective-C syntax can appear really foreign and since Apple doesn't embed much if any sample code in their Cocoa documentation, learning this stuff is kind of difficult.