Device interrupts themselves are (usually) processed by whatever thread had the CPU that took the interrupt, but in a ring 0 and at a different protection level. This limits some of the actions an interrupt handler can take, because most of the time the current thread will not be related to the thread that is waiting for the event to happen that the interrupt is indicating.
The kernel itself is closed source, and only documented through its internal API. That API is exposed to device driver authors, and described in the driver development kits.
Some resources to get you started:
Any edition of Microsoft Windows Internals by Solomon and Russinovich. The current seems to be the 4th edition, but even an old edition will help.
The Windows DDK, now renamed the WDK. Its documentation is available online too. Be sure to read the Kernel Mode Design Guide...
Sysinternals has tools and articles to probe at and explain the kernel's behavior. This used to be an independent site until Microsoft got tired of Mark Russinovich seeming to know more about how the kernel worked than they did. ;-)
Note that source code to many of the common device drivers are included in the DDK in the samples. Although the production versions are almost certainly different, reading the sample drivers can answer some questions even if you don't want to implement a driver yourself.