I really don't want to be a party pooper but I don't think PHP4 / 5 support / speed or the auto loading feature being a PHP4 hack and whether or not it maintains singleton classes really is that relevant.
It seems the real pro's, who actually know what the above means and can demonstrate the differences between PHP 4 / 5 speed and pinpoint where and why in the application this effect is caused, would use more enterprise frameworks like Zend or Cake.
Speed of the app – unless you are trying to make your app slow, any php framework will deliver decent enough speed for small applications. Only if you're on a site with 10.000's of users per day will this start to matter.
I have only experience with CodeIgniter and I use to build small/midsized company websites and intranet applications because :
- it allows me to do so quickly
- keeps code clean via MVC
- documentation is the best i've ever seen
- usually things work exactly as indicated: very few bugs or quirks
All the technical nitty gritty is not really that important.
The community "model" – I'd much rather have a bunch of core-guys from Ellislab who communicate clearly and honestly and release code that works perfectly 99% of the time, than a model like Drupal's where anyone can upload a module and you discover 3 months down the line it actually doesn't work at all like it should, no support it available and you're fcked.
So concluding, I would say go with CI if you want robust documentation to help you deliver your product on time. If you're really good with PHP and like experimenting and digging in the code, then try Kohana.
Best of luck!