Since sqlite is transactional, it relies on fsync to ensure a particular set of statements have completed when a transaction is committed. The speed and implementation of fsync varies from platform to platform.
So, by batching several statements within a transaction, you can get a significant increase in speed since several blocks of data will be written before fsync is called.
An older sqlite article here illustrates this difference between doing several INSERTs inside and outside transactions.
However, if you are writing an application needing concurrent access to data, note that when sqlite starts a write transaction, all reads (select statements) will be blocked. You may want to explore using your in memory cache to retrieve data while a write transaction is taking place.
With that said, it's also possible that sqlite's caching scheme will handle that for you.